Phenanthrenes and derivatives
Sigma Aldrich Gum Rosin
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 9,10-Dihydrophenanthrene
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 4-(Trifluoromethyl)cyclohexylamine
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 4-Nitro-1H-pyrrole-2-carboxylic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Fullerene-C60
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Cayman Chemical ArIstolochIc AcId 25mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
Accela Chembio Inc Triphenylene | 25g | 217-59-4 | MFCD00001108 | 97+% | Shelf Life: 900 Days | Light Sensitive
Triphenylene | 25g | 217-59-4 | MFCD00001108 | 97+% | Shelf Life: 900 Days | Light Sensitive
Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.
Medchemexpress LLC Aristolochic acid D (Aristolochic acid-IVa) | 17413-38-6 | 357.27 | 1 MG
Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 and CDK2 inhibitor isolated from *Aristolochia indica L.* It exhibits anti-inflammatory activity and can be used in the research of inflammation and tumor-related diseases.
- Orally active PDE2 inhibitor
- Orally active CDK2 inhibitor
- Isolated from *Aristolochia indica L.*
- Exhibits anti-inflammatory activity
- Non-carcinogenic
- Non-nephrotoxic
- Can be used in inflammation research
- Can be used in tumor-related diseases research
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 100 MG
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to ubiquitination and subsequent degradation of BCR-ABL1. It is for research use only and not sold to patients.
- Allosterically targets the BCR-ABL1 protein.
- Recruits the E3 ligase Von Hippel-Lindau for ubiquitination and degradation of BCR-ABL1.
- Exhibits cell proliferation with IC50 values of 1.11, 1.98, and 0.37 μM for BCR-ABL1 WT, T315I, and G250E cells.
- Induces the degradation of BCR-ABL1 and c-ABL1.
- Inhibits downstream signaling via the STAT5 pathway in K562 and Ba/F3 cells.
- Intended for research use only.
Medchemexpress LLC Aristolochic acid D (Aristolochic acid-IVa) | 17413-38-6 | 357.27 | 1 ML
Aristolochic acid D (Aristolochic acid-IVa) is an orally active inhibitor of PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) that is isolated from Aristolochia indica L. It demonstrates anti-inflammatory activity and is considered non-carcinogenic and non-nephrotoxic. This compound is suitable for research related to inflammation and tumor-related diseases.
- Orally active PDE2 inhibitor (IC50: 4.673 μM).
- CDK2 inhibitor (IC50: 25 μM).
- Isolated from Aristolochia indica L.
- Exhibits anti-inflammatory activity.
- Non-carcinogenic.
- Non-nephrotoxic.
- Useful in research for inflammation and tumor-related diseases.
Medchemexpress LLC 2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-, (3R,4S)-rel- | 1213777-80-0 | 99.9% | C22H20O4 | 10MG
Triphen diol is a phenol diol derivative reported to have anticancer activity against pancreatic cancer and cholangiocarcinoma. It induces apoptosis through caspase-mediated and caspase-independent mechanisms and is supplied as a high-purity research reagent for laboratory studies.
- Phenol diol derivative with reported anticancer activity.
- Induces apoptosis via caspase-mediated and caspase-independent pathways.
- High purity (~99.9%) suitable for research applications.
- Molecular formula C22H20O4; molecular weight 348.39 g·mol⁻¹.
- Soluble in DMSO (≈100 mg/mL); use freshly opened solvent to ensure solubility.
- Store protected from light; in solvent store short-term at -20°C and long-term at -80°C.
Medchemexpress LLC 6-aminochrysene | 2642-98-0 | MFCD00003699 | 99.7% | 243.30 g/mol | C18H13N | 50 MG
6-Aminochrysene is an aromatic amine research compound (CAS 2642-98-0) used in laboratory studies. The light yellow solid has molecular formula C18H13N and a molecular weight of 243.30 g/mol. The supplier lists high purity, DMSO solubility data, storage recommendations for powder and solutions, and multiple small pack sizes for research use.
- Light yellow to yellow solid appearance.
- Molecular formula C18H13N and molecular weight 243.30 g/mol.
- High purity (99.7%).
- Soluble in DMSO (100 mg/mL); sonication recommended.
- Recommended storage conditions provided for powder and in-solution forms.
- Available in small research pack sizes, including 50 mg.
Medchemexpress LLC Hypericin | 548-04-9 | 504.443 | 1 MG
Hypericin is a naturally occurring substance found in Hypericum perforatum L. It functions as an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP (cytochrome P450). It exhibits antitumor, antiviral, and antidepressive activities, and can induce apoptosis.
- Inhibits PKC (protein kinase C)
- Inhibits MAO (monoaminoxidase)
- Inhibits dopamine-beta-hydroxylase
- Inhibits reverse transcriptase
- Inhibits telomerase
- Inhibits CYP (cytochrome P450)
- Shows antitumor activity
- Shows antiviral activity
- Shows antidepressive activity
- Induces apoptosis
- Relevant for infection research
- Relevant for neurological disease research
- Relevant for cancer research